Tyrosine kinase inhibitors

Clinical development of tyrosine kinase inhibitors targeted platelet-derived growth factor receptor

靶向血小板源生长因子受体酪氨酸激酶抑制剂的临床研究进展

Flexible Atom Receptor Model Study on Tyrosine Kinase Inhibitors

酪氨酸激酶抑制剂的柔性原子受体模型方法研究

Comparative Molecular Field Analysis of Tyrosine Kinase Inhibitors

酪氨酸激酶抑制剂的比较分子场分析

Molecular Design and Biological Activity of BCR-ABL Tyrosine Kinase Inhibitors

BCR-ABL酪氨酸激酶抑制剂的分子设计及其生物活性

Progress of epidermal growth factor receptor and tyrosine kinase inhibitors in the cancer therapy

表皮生长因子受体与酪氨酸激酶抑制剂在肿瘤防治中的应用进展

Currently , several EGFR tyrosine kinase inhibitors are in clinical trial stage .

目前，已有几种EGFR酪氨酸激酶抑制剂进入了临床试验。本文对几种EGFR酪氨酸激酶小分子抑制剂在肿瘤治疗中的研究进展做一综述。

Effect of Tyrosine Kinase Inhibitors on Airway Remodeling in Bronchial Asthma

酪氨酸激酶抑制剂对哮喘气道重构的影响

Advances in the research of multi-target tyrosine kinase inhibitors

多靶点抗肿瘤酪氨酸激酶抑制剂的研究开发

Establishment of homogeneous time-resolved fluorescence immunoassay for high throughput screening of protein tyrosine kinase inhibitors

用于蛋白酪氨酸激酶抑制剂高通量筛选的均相时间分辨荧光免疫方法的建立

The structures and functions of EGFR as well as current status of EGFR tyrosine kinase inhibitors are reviewed .

综述了EGFR的结构和作用以及近年来EGFR酪氨酸激酶抑制剂的研究进展。

So , dual receptor tyrosine kinase inhibitors targeting both EGFR and HER-2 may increase the response rate .

因此开发针对EGFR和HER-2双靶点的酪氨酸激酶抑制剂将会提高肿瘤治疗的疗效。

Conclusion : This system has a character of high speed , convenience and high throughput in screening of tyrosine kinase inhibitors in vitro .

结论：建立的方法具有快速、简便可行、高通量的特点，可用于蛋白酪氨酸激酶抑制剂的体外筛选。

Objective To investigate the effect of tyrosine kinase inhibitors ( TKIs ) on asthmatic rat airway remodeling .

目的探讨酪氨酸激酶抑制剂（TKIs）对支气管哮喘大鼠气道重构的影响。

This paper is to review the current advance of the small molecular targeted anti-tumor agents Tyrosine Kinase Inhibitors and their mechanisms of action .

本文综述了一类靶向抗肿瘤药物&蛋白酪氨酸激酶抑制剂的研究进展，并讨论这类药物的靶向抗肿瘤机制。

Response rates to epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors in cancer treatment have been surprisingly and disappointingly low .

EGFR酪氨酸激酶抑制剂在肿瘤的治疗中的反应率是出乎意料和令人失望的低。

Objective To build3D-pharmacophore model of epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors using distance comparisons method and design novel EGFR inhibitors .

目的构建表皮生长因子受体（EGFR）抑制剂的药效团模型，设计新结构类型的化合物。

We synthesized series of new protein tyrosine kinase inhibitors based on the structure of flavonoid we had . Preliminary determination is carried out on their anti-cancer effect .

本研究在已报道具有蛋白酪氨酸激酶抑制活性的黄酮类结构的基础上，进行结构修饰，设计并合成了一系列化合物，并对其药理活性进行初步测定，旨在发现新的抗肿瘤药物。

The activity of the synthetic compounds is coincident with the target structures . It showed that the compounds maybe multi-target protein tyrosine kinase inhibitors . 3 .

化合物的活性与目标一致，表明其作用机制可能是多靶点的酪氨酸激酶抑制剂。

Drugs targeting EGFR receptors have already been successfully implicated in clinic and all belong to two categories : monoclonal antibodies and tyrosine kinase inhibitors ( TKIs ) .

靶向EGFR家族的抗肿瘤药物可以分为单克隆抗体和小分子酪氨酸激酶抑制剂两大类。

Tyrosine kinase inhibitors and mitosis inhibitors are powerful anticancer drugs . Research and development of tyrosine kinase inhibitor and mitosis inhibitors have become a hotpot in the research area of anti-anticancer drugs .

小分子酪氨酸激酶抑制剂和有丝分裂抑制剂均为有效的抗肿瘤药物，对激酶抑制剂和有丝分裂抑制剂的研究与开发已成抗肿瘤药物研究的热点领域。

Three dimensional quantitative structure activity relationships of isoflavone and quinolone derivatives as tyrosine kinase inhibitors were studied using the flexible atom receptor model ( FLARM ) method . Some 3D QSAR models were built with high correlation coefficients .

利用柔性原子受体模型（FLARM）方法对一系列的异黄酮和喹诺酮衍生物表皮生长因子受体酪氨酸激酶抑制剂进行了三维定量构效关系研究，得到了合理的构效关系模型。

Objective : To investigate the effect of the expression of c-Kit protein and its relationship with clinical pathology and prognosis of SCLC . To discuss the rationale for and development of tyrosine kinase inhibitors for the treatment of human SCLC .

目的：探讨c-Kit基因蛋白在肺小细胞癌（SCLC）中的表达情况及其与临床病理、预后的关系，展望酪氨酸激酶抑制剂应用于SCLC治疗之中的前景。

Genistein is a kind of soy isoflavones , and also a kind of tyrosine kinase inhibitors , which widespreads in legumes such as broom , acacia , huaijiao and other medicinal plants and whose content is rich in soybean hypocotyl .

染料木素，是一种大豆异黄酮类化合物，同时还是酪氨酸激酶抑制剂，具有雌激素样作用，广泛存在于金雀花、皂荚、槐角等豆科药用植物中，在大豆胚轴中含量也较为丰富。

Design and Synthesis of Novel Quinazoline Derivatives as Tyrosine Kinase Chemical Inhibitors

新型喹唑啉类酪氨酸激酶化学抑制剂的设计与合成

Quantum-chemical studies on quantitative structure-activity relationship of tyrosine protein kinase inhibitors

酪氨酸蛋白激酶抑制剂：亚苄基丙二腈类衍生物定量构效关系的量子化学研究

CONCLUSION : CD117 can be regard as the related tumor antigen of MM , and may be a valuable marker in the use of tyrosine kinase selective inhibitors , which inhibit the signal conduct to the target .

结论CD117可作为MM的肿瘤相关抗原，也可作为靶向信号转导抑制剂酪氨酸激酶选择性抑制剂应用的有价值的标志。

BACKGROUND & OBJECTIVE : Leukocyte differentiation antigen CD117 is one of the targets that tyrosine kinase selective inhibitors work on . Whether CD117 is expressed on the cell surface , and the expression level are highly correlated with tyrosine kinase selective inhibitors .

背景与目的细胞表面分化抗原CD117是酪氨酸激酶选择性抑制剂作用的靶点之一，细胞表面是否表达CD117及表达的量与酪氨酸激酶选择性抑制剂作用关系密切。

OBJECTIVE : To discuss the progress and the clinical application evaluation of protein tyrosine kinase ( PTK ) inhibitors .

前言：目的：探讨酪氨酸激酶抑制剂的进展与临床应用评价。

Purpose : A rapid screening method for protein tyrosine kinase ( PTK ) inhibitors was established for drug screening in vitro and several experimental conditions had been studied . A series of curcumin derivatives was screened by the method and some of them owing PTK inhibitory activity were obtained .

目的：进行相关实验条件的摸索，建立蛋白酪氨酸激酶（PTK）抑制剂的快速筛选方法，并应用此方法对姜黄素衍生物进行体外筛选，得到有抑制蛋白酪氨酸激酶活性的衍生物。